Doctoral program in applied areas of biological and biomedical sciences.
The HBKU Biological and Biomedical Sciences (BBS) PhD is a multidisciplinary graduate program that aims to train the next generation of leaders in biomedical sciences.
The PhD degree path offers students an education that provides them with an advanced level of knowledge – particularly in applied areas of biological and biomedical sciences – and develops critical and independent reasoning skills.
Students take their core and elective course requirements in the first two to three semesters in the program and should aim to begin their thesis research no later than the second semester in the program.
During their tenure in the PhD program, students will have regular meetings with their Research Advisory Committee (RAC) -- a committee that will give advice and help oversee the student’s progress.
In Year 2, students take the Candidacy Examination.This exam determines whether the student is ready to begin a period of research aimed towards a doctorate degree. The examination provides the Candidacy Examination Committee and the student with means to assess the student’s mastery of the basic body of knowledge and development of the breadth and depth of scholarship that is expected of PhD candidates.
After Year 3, students take the Comprehensive Examination. This exam allows the Graduate Advisory Committee to thoroughly examine the student's preparation for dissertation research. Successful completion of the comprehensive examination indicates that the student has a broad and in-depth background in biomedical sciences. It marks the watershed from taking courses to being a full-time researcher.
To obtain their PhD, a student will have to write their dissertation and successfully defend it orally.
This course is a foundational course for graduate students who will be engaged in research. It provides students with an introduction to ethics and ethical misconduct, intellectual property and environmental health and safety as well as scientific thought and design of experiments. A focus of the course is to transition students from textbooks to primary literature as their main source of information.
This is an introductory course on probability theory and statistics, which will cover fundamental principles of statistics and their applications in science and engineering.
Course topics will include:
This course covers the important principles in Molecular Biology, including the replication of DNA, how DNA is converted to RNA, how RNA is modified, transported and regulated, and finally how it is converted to protein. Through the use of primary literature papers, students will gain a current understanding of these subjects.This course covers the important principles in Molecular Biology, including the replication of DNA, how DNA is converted to RNA, how RNA is modified, transported and regulated, and finally how it is converted to protein. Through the use of primary literature papers, students will gain a current understanding of these subjects.
This course builds on the knowledge students acquired in Advanced Molecular Biology and covers the important principles of Cell Biology, the study of the basic unit of life. By relying heavily on recently published, seminal scientific papers, students will acquire an accurate understanding of the current research progress in key areas in cell biology.
This course is designed to train students in a range of standard biochemical and cellular biology techniques that are in routine use in a functioning biochemistry laboratory. The course combines lectures illustrating the scientific principles underlying a particular technique with hands-on experience of the methodology in the laboratory. Techniques include protein expression, purification, gel analysis, protein structure and cell culture.
This course will engage students in a detailed exploration of the most important neurological disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD) and prion diseases. With an initial focus on clinical descriptions for each condition, an in-depth discussion on current hypotheses about the mechanisms underlying these diseases will constitute the bulk of this course.
In this course, students will be exposed to the latest findings in the molecular mechanisms that underlie the genesis and progression of human cancers. Lectures and discussions will be based entirely upon the current scientific literature. These papers will highlight how perturbation of the cell cycle, DNA damage checkpoints, and repair machinery can both promote cancer and be capitalized upon for cancer treatment.
This is an introductory course for bioinformatics, whose main goal is to provide an in-depth introduction to several probabilistic and statistical models as well as algorithms and techniques that are widely used in bioinformatics, especially, for the analysis of biological sequences.
Course topics will include:
1)Sequence alignment techniques
2)Markov chains and hidden Markov models (HMMs)
4)Stochastic context-free grammars (SCFGs)
5)RNA folding and alignment
6)Other emerging topics in bioinformatics
This course is intended as an introduction and in-depth discussion focused on the biology of stem cells. The course will introduce the features of stem cells and basic mechanisms regulating their self-renewal and pluripotency. In addition, the course will focus on selected examples of adult stem cells with an introduction to translational medicine approaches involving stem cell biology. Major emphasis will be placed on how advances in stem cell biology and tissue engineering can be applied to the use of embryonic and adult stem cells in regenerative medicine. In addition to these topics, students will be introduced to the ethical, regulatory, and legal issues related to stem cell research.
The field of immunology has witnessed a huge surge in knowledge in the last 40 years. From relatively modest and rather esoteric beginnings, immunology has become one of the most dynamic and exciting areas of medical sciences. This course encompasses the major sub-disciplines in the field. These will include, but not be limited to, development and maturation of the various cell lineages of the immune system, phylogeny and structure-function relationship of cell-associated as well as soluble receptors used by the immune system, the mechanisms of antigen processing, presentation, and recognition, properties of innate vs. adaptive immune responses, communication and cell-cell interactions, immunoregulation, and humoral and cellular effector mechanisms.
This course provides students with knowledge in microbial communities and their distribution in the environment; microbial pathogens and their transmission pathways in water, air, soil and food; and the various sources of microbial contamination in the environment. This course also covers environmental applications of molecular technology and other advanced detection tools. Furthermore, emerging issues, such as health implications of nanotechnology, renewable energy, climate change and infectious disease, urban microbiology, and food safety will be discussed to give insight to future environmental health concerns.
This course is intended for graduate students interested in gaining a detailed understanding of molecular mechanisms underlying synaptic function and development. Throughout the course, the focus will be on understanding the experimental approaches that produced current knowledge. In most weeks, students will be assigned recent research papers as their primary reading material. About 2/3 of the classes will be lectures by the instructor and 1/3 will be student led discussions of papers.
The aim of the course is to provide an introduction to epigenetics and chromatin dynamics, particularly the structural and biochemical modifications of chromatin that underlie epigenetic states and their effects on gene expression and human diseases. The importance of epigenetic states is perhaps the major discovery of molecular biology in the past ten years. They are critical to understanding the control of gene expression in development, the programming and reprogramming that takes place in the differentiation of pluripotent stem cells and they provide an accounting for many of the genomic malfunctions that result in human disease. An acquaintance with the concepts of what has come to be known as Epigenomics is essential for a Molecular Biology major.
Independent Study in Life Sciences allows students to examine a variety of timely, cutting-edge research areas. Taught by our faculty or/and research scientists from our research institutes or industrials, this course allows students to keep up with critical trends and topics in the field. Registration for this course requires Program Coordinator and Instructor approval. In addition, a student can only register for this course once during their tenure at HBKU.Independent Study in Life Sciences allows students to examine a variety of timely, cutting-edge research areas. Taught by our faculty or/and research scientists from our research institutes or industrials, this course allows students to keep up with critical trends and topics in the field. Registration for this course requires Program Coordinator and Instructor approval. In addition, a student can only register for this course once during their tenure at HBKU.
This course provides a comprehensive, bottom-up coverage of how biosensors are engineered starting from physical transduction and electrical detection all the way to signal conditioning and processing. The course is structured around sensing principles including physical phenomenon as well as electronics (VLSI circuits) of the different sensory systems and processing of bio-sensing signals.