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Dr. Yongsoo Park
Senior Scientist Joint Assistant Professor
Dr. Yongsoo Park
Senior Scientist Joint Assistant Professor
Educational Qualifications
PhD in Molecular Neurobiology
BS in Life Science
Entity
Qatar Biomedical Research Institute
College of Health and Life Sciences
Biography
Dr. Yongsoo Park is a Scientist at the Qatar Biomedical Research Institute (QBRI) and an Assistant Professor at the College of Health & Life Sciences, Hamad Bin Khalifa University, where he models neurological diseases using patient-specific hiPSC-derived neurons.
Dr. Yongsoo Park received his PhD in investigating exocytosis and plasticity of vesicle fusion at the POSTECH (Pohang University of Science and Technology), South Korea. After completing his PhD degree in 2009, he worked as a postdoctoral researcher at the Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany, being trained by mentor Prof. Reinhard Jahn, a world-renowned scientist by his pioneering research into fusion and neurotransmitter release.
In 2015, Dr. Yongsoo was appointed as an Assistant Professor at the Izmir International Biomedicine and Genome Institute and joined the Department of Molecular Biology and Genetics at the Koç University, Istanbul, Turkey.
His lab at QBRI focuses on extracellular vesicle biomarkers for autism spectrum disorder (ASD), Parkinson’s disease, and Alzheimer's disease. He also studies lipid dysregulation in neurological disease conditions with a focus on vesicle fusion. By applying interdisciplinary approaches, his team investigates molecular mechanisms of neurodegenerative diseases and the development of therapeutics to treat neurological diseases.
PhD in Molecular Neurobiology
POSTECH (Pohang University of Science and Technology), South Korea
2009
BS in Life Science
Handong Global University, South Korea
2001
- Exosome and extracellular vesicle biomarkers for neurological disorders including autism spectrum disorder (ASD).
- Use of neuronal differentiation of human induced pluripotent stem cells (hiPSC) as a disease model of ASD, Alzheimer's disease, and Parkinson’s disease.
- Lipid dysregulation in neurological disease condition with a focus on vesicle fusion.
- Molecular mechanisms of neuronal degeneration in Parkinson’s disease and microRNA exocytosis in health and disease.
Scientist
Qatar Biomedical Research Institute, Hamad Bin Khalifa University
2019 – Present
Assistant Professor
College of Health and Life Sciences, Hamad Bin Khalifa University
2019 – Present
Assistant Professor
Department of Molecular Biology and Genetics, Koç University, Istanbul, Turkey
2017 – 2019
Assistant Professor
Izmir International Biomedicine and Genome Institute, Turkey
2015 – 2017
Postdoctoral Researcher
Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany
2009 – 2015
Shin, K. C., Ali Moussa, H. Y., & Park, Y. (2024). Cholesterol imbalance and neurotransmission defects in neurodegeneration. Experimental & Molecular Medicine. Review. Accepted.
Ali Moussa, H. Y., Shin, K. C., Ponraj, J., Park, S. H., Lee, O. S., Mansour, S., & Park, Y. (2024). PIP2 is an electrostatic catalyst for vesicle fusion by lowering the hydration energy: Arresting vesicle fusion by masking PIP2. ACS Nano, 18(20), 12737–12748. Highlighted as a supplementary cover.
Shin, K. C., Ali, G., Ali Moussa, H. Y., Gupta, V., de la Fuente, A., Kim, H. G., Stanton, L. W., & Park, Y. (2023). Deletion of TRPC6, an autism risk gene, induces hyperexcitability in cortical neurons derived from human pluripotent stem cells. Molecular Neurobiology, 60(12), 7297–7308.
Ali Moussa, H. Y., Shin, K. C., Ponraj, J., Kim, S. J., Ryu, J. K., Mansour, S., & Park, Y. (2023). Requirement of cholesterol for calcium-dependent vesicle fusion by strengthening synaptotagmin-1-induced membrane bending. Advanced Science, 10(15), e2206823. Highlighted as a frontispiece.
Ali Moussa, H. Y., Manaph, N., Ali, G., Maacha, S., Shin, K. C., Ltaief, S. M., Gupta, V., Tong, Y., Ponraj, J., Salloum-Asfar, S., Mansour, S., Al-Shaban, F. A., Kim, H. G., Stanton, L. W., Grivel, J. C., Abdulla, S. A., Al-Shammari, A. R., & Park, Y. (2022). Single extracellular vesicle analysis using flow cytometry for neurological disorder biomarkers. Frontiers in Integrative Neuroscience, 16, 879832.
Complete Publication Listing(s): NCBI
- Member, International Advisory Board of the International Symposium on Chromaffin Cell Biology (ISCCB)(2023).
- Best faculty/researcher poster award, second place, the 1st HBKU Research Day (7.Sep.2022).
- Member, EMBO Young Investigator Programme (YIP) as an EMBO Installation Grantee (2016-2020)).
- Science Academy’s Young Scientist Awards Program (BAGEP), Bilim Akademisi, Turkey (27. 04. 2017).
- Research fellowship for post-doctoral researcher, Alexander von Humboldt Foundation (2010 – 2012).