Dr. Mustapha Aouida
Research Scientist & Lab Manager
Dr. Mustapha Aouida
Research Scientist & Lab Manager
Educational Qualifications
PhD in Biology (Molecular and Cell Biology)
Master Degree in Microbiology
Entity
College of Health and Life Sciences
Biography
Dr. Mustapha Aouida received his PhD in Molecular and Cell Biology in 2003 from both the Science University of Tunis and Gustave Roussy Institute, Paris. For his post-doctoral fellowship he joined Professor Ramotar at Maisonneuve-Rosemont Research Institute in Montreal where he studied the mechanism by which yeast cells and mammalian cells become resistant to the antitumor drug bleomycin. Dr. Aouida joined the College of Health and Life Sciences in April 2016 as a Lab Manager and is currently a Research Scientist at the college.
PhD in Biology (Molecular and Cell Biology)
Gustave Roussy Institute, Paris (France); Science University Of Tunis, Tunisia
2003
Master Degree in Microbiology
Science University Of Tunis, Tunisia
1999
Bachelor in Natural Sciences
Bachelor in Natural Sciences
1997
High School diploma in Science
Technical High School Zarzis, Tunisia
1993
Research Scientist
College of Health and Life Sciences
2019 - Present
Lab Manager
Division of Life Sciences, College of Science and Engineering, Hamad Bin Khalifa University
2016 - 2018
Research Scientist
Genome Engineering Laboratory, King Abdullah of Science and Technology
2010 - 2015
Postdoctoral Research Scientist
Maisonneuve Research Center, University of Montreal
2003 - 2010
- Yeast lacking the PP2A phosphatase regulatory subunit Rts1 sensitizes rad51 mutants to specific DNA damaging agents. Front. Genet. 2019 Nov 8;10:1117. doi: 10.3389/fgene.2019.01117. eCollection 2019
- The Budding Yeast Saccharomyces Cerevisiae as A Model System for Anti-Cancer Drug Screening. Clinics of Oncology 1 (6) 1-3.
- Identification of essential yeast genes involved in polyamine resistance. Gene https://doi.org/10.1016/j.gene.2018.08.066 In press
- CRISPR/Cas9-mediated target validation of the splicing inhibitor Pladienolide B. Biochimie Open. 2016 Feb 24;3:72-75. doi: 10.1016/j.biopen.2016.02.001. eCollection 2016 Dec.
- Generation of an Efficient fdCas9 Synthetic Endonuclease with Improved Specificity for Precise Genome Engineering. PLoS One. 2015 Jul 30;10(7):e0133373. doi: 10.1371/journal.pone.0133373. eCollection 2015.
- Efficient Viral-Mediated Genome Editing in Plants using the CRISPR/Cas9 System (2015). Mol Plant. 2015 Mar 6. pii: S1674-2052(15)00162-8. doi: 10.1016/j.molp.2015.02.011
- The use of transcription activator- J Biosci Bioeng. 2015 Apr 20. pii: S1389-1723(15)00095-X. doi: 10.1016/j.jbiosc.2015.02.017
- RNA-guided transcriptional regulation in planta via synthetic dCas9- based transcription factors. Plant Biothechnology 2015 May; 13(4):578-89.
- Activities and Specificities of homodimeric TALENs in Saccharomyces cerevisiae. Current genetics (2013). In press
- A split luciferase method to identify Adiponectin receptors agonists using Saccharomyces cerevisiae as a model organism. PLoS One. 2013 Jun 7;8(6):e65454. doi: 10.1371/journal.pone.0065454. Print 2013
- AGP2 Encodes a Multifunctional Transceptor that Positively Regulates Polyamine Transport. PLoS One. 2013 Jun 3;8(6):e65717. doi: 10.1371/journal.pone.0065717. Print 2013
- Characterization and DNA Binding Specificities of Ralstonia TAL-like Effectors. Mol Plant. 2013 Jan 8.
- Book Chapter, DNA repair in cancer therapy Cancer Drug Discovery and Development (2012) Edited by Lawrence C. Panasci and Moulay A. Alaoui-Jamali In Press.
- Functional Characterization of Osput1 A Spermidine Preferential Transporter In Rice. Planta (2012) Jan;235(1):1-11.
- A potential transporter to revamp therapy with the anticancer drug bleomycin. Curr Drug Metab. 2010 Sep; 11(7):595-602.
- Internalization of a thiazole-modified peptide in Sinorhizobium meliloti occurs by BacA – dependent and independent mechanisms. Microbiology, 2010 Sep; 156(Pt 9): 2702 -13
- New Gateway to Treat Leukemia and Other Cancers, Science Daily (Mar, 27, 2010). http:// www.sciencedaily.com/releases/2010/03/100325113425.htm
- The Human Carnitine Transporter SLC22A16 Mediates High Affinity Uptake of the Anticancer Polyamine Analogue Bleomycin-A5 J. Biol. Chem. 2010 285: 6275-6284
- The Na+/H+ Exchanger Nhx1 of Saccharomyces cerevisiae is Essential to Limit Drug Toxicity. Advanced Studies in Biology, Vol. 2, 2010, no. 1, 15 – 34
- Novel role for the Saccharomyces cerevisiae oligopeptidetransporter Opt2 in vacuolar assembly and drug detoxification. Biochem and Cell Biology 2009: Vol 87 653-661.
- A potential mechanism of resistance to the anticancer drug bleomycin. In: Mohan RM, editor. Research Advances in Cancer: Vol., Part, Kerala, India, Global Research Network 247-260, 2007.
- Mitochondria-independent morphological and biochemical apoptotic alterations promoted by the antitumor agent bleomycin in S. cerevisiae. (2007) Biochemistry and Cell Biology. Vol. 85 No. 1 Pages 49-55.
- Bleomycin transport holds the key for improved anticancer therapy. Review Article. (2006). Cancer Therapy Vol 4, 171-182.
- A defect (spt10) in chromatin remodeling sensitizes yeast cells to a subclass of DNA damaging agents. (2006). Environ Mol Mutagen. 47(9):707-17.
- AGP2 encodes the major permease for high affinity polyamine import in Saccharomyces cerevisiae. J Biol Chem. (2005): 280(25): 24267-24276
- Isolation and characterization of Saccharomyces cerevisiae mutants with enhanced resistance to the anticancer drug bleomycin. Current Genet. 2004 May; 45(5):265-72
- A genome-wide screen in Saccharomyces cerevisiae reveals altered transport as a major mechanism of resistance to the anticancer drug bleomycin. Cancer Res. 2004 Feb 1; 64(3):1102-9.
- Characterization of the transport and detoxification pathway for the antitumor drug bleomycin in Saccharomyces cerevisiae. Biochem J. 2004 Nov 15; 384(Pt 1):47-58.
- Etude comparative de la cytotoxicité de deux antibiotiques antitumoraux, la bléomycine et laphléomycine, sur trois souches de la levure Saccharmyces cerevisiae. Microbiologie Hygiene et Alimentaire Vol. 16 :46 (2004) : 44-50.
- Comparative roles of cell wall and cell membrane in limiting xenobiotic molecules uptake by Saccharomyces cerevisiae. Antimicrobial Agents and Chemotherapy 2003 Jun; 47(6):2012-4.
- Yeast excellent model to study apoptosis. Microbiologie Hygiene et Alimentaire Vol.15 :42 (2003).
- 2005-2008 Post PhD fellowship from National Cancer Institute of Canada
- 2003-2005 Scholarship from Maisonneuve-Rosemont Foundation, Montreal (University of Montreal)
- 1999-2003 Scholarship from Tunisian Government and second scholarship from CNRS-France
- 1993-1999 Scholarship from Tunisian Government