Neuro-immune crosstalk in Autism Spectrum Disorder

Identification of immune risk factors for Autism Spectrum Disorder (ASD) and determining their functional impact on brain development and function

Autism spectrum disorder (ASD) is a lifelong developmental condition where affected individuals suffer from difficulties in social communications and interactions, while displaying restricted, repetitive behaviours. While the exact cause of ASD is still unclear, both genetic and environmental factors are likely to increase the risk. The immune system is the first route of contact and response to the external environment. Dr. Al-Shammari’s current research focus is on understanding the role of the immune system in ASD. This is important since the immune condition affects brain function and behaviour. Another aim is to study the interaction between the neuro and immune system in ASD. Together, these aims are interdisciplinary with a future potential not only for targeting immune cells for autism therapy, but also for enhancing our fundamental understanding of the crosstalk between the immune system and the brain.