Henning F. Horn | Hamad Bin Khalifa University

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Hamad Bin Khalifa University

FACULTY BIOGRAPHIES

Henning F. Horn

Dr. Henning F. Horn (PhD)

Associate Professor of Practice
College of Health and Life Sciences

Biography

Dr. Horn received his PhD in Cell and Molecular Biology in 2003 from the University of Cincinnati College of Medicine. His dissertation work looked at the role of cell cycle regulatory proteins in centrosome duplication. For his post-doctoral fellowship he joined Professor Karen Vousden at the Beatson Institute for Cancer Research in Glasgow, UK where he studied the role of ribosomal stress in activating the tumor suppressor p53 pathway. From 2008 until 2014 he worked with Professors Colin Stewart and Brian Burke at the Institute of Medical Biology in Singapore. There he analyzed several mouse models of nuclear envelope proteins, and elucidated novel roles for these proteins in gametogenesis as well as hearing loss. Dr. Horn has been an Assistant Professor at HBKU since September 2014.

 

Research Interests

The role of nuclear envelope proteins in cellular organization and mechanobiology. These processes play an important role in several diseases. Dr. Horn's research is focused on the role of nuclear envelope proteins in two such health issues: hearing loss and infertility.

Experience

Assistant Professor

Division of Life Sciences, College of Science and Engineering, Hamad Bin Khalifa University

2014 to present

  • Senior Research Fellow

    The Institute of Medical Biology, A*STAR, Singapore

    2008 - 2014

  • Postdoctoral Research Scientist

    The Beatson Institute for Cancer Research, Glasgow, UK

    2003 - 2008

  • Graduate Student

    Graduate Program in Cell and Molecular Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

    1998 - 2003

Education

PhD Cell and Molecular Biology

University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. “The Role of p21CIP1/WAF1 and CDK2/Cyclin E in Regulating Centrosome Duplication”

2003

  • BA summa cum laude, Phi Beta Kappa. Biology

    Wittenberg University, Springfield, Ohio, USA.

    1997

Selected Publications

  • Lee CY, Horn HF, Stewart CL, Burke B, Bolcun-Filas E, Schimenti JC, Dresser ME, Pezza RJ. Mechanism and Regulation of Rapid Telomere Prophase Movement in Mouse Meiotic Chromosomes.

    Cell Reports. 2015 Apr 16.

     2015

  • Wang AS, Kozlov SV, Stewart CL, Horn HF. Tissue specific loss of A-type lamins in the gastrointestinal epithelium enhances polyp size.

    Differentiation. 2015 Jan 8.

     2015

  • Horn HF*, Kim DI*, Wright G, Stewart CL, Burke B, and Roux KJ. A mammalian KASH domain protein coupling meiotic chromosomes to the cytoskeleton. Journal of Cell Biology. 2013 Sep 30;202(7):1023-1039. *Co-first authors. Article Featured in “In This Issue

    Winner of the Outstanding Paper Award 2013, the European Microscopy Society; category “Life Sciences”.

     2013

  • Horn HF*, Brownstein Z*, Lenz DR, Shivatzki S, Dror AA, Dagan-Rosenfeld O, Friedman LM, Roux KJ, Kozlov S, Jeang KT, Frydman M, Burke B, Stewart CL, Avraham KB. The LINC complex is essential for hearing. The Journal of Clinical Investigation. 2013 Feb;

    The Journal of Clinical Investigation. 2013 Feb;123(2):553-555.

     2013

  • Horn HF, Vousden KH. Cooperation between ribosomal proteins L5 and L11 in the p53 pathway. Oncogene.

    2008 Oct 2;27(44):5774-84.

     2008

  • Bernardi R, Scaglioni PP, Bergmann S, Horn HF, Vousden KH, Pandolfi PP. PML regulates p53 stability by sequestering Mdm2 to the nucleolus.

    Nature Cell Biology. 2004 Jul;6(7):665-72.

     2004

  • Tarapore P, Tokuyama Y, Horn HF, Fukasawa K. Difference in the centrosome duplication regulatory activity among p53 'hot spot' mutants: potential role of Ser 315 phosphorylation-dependent centrosome binding of p53. Oncogene.

    2001 Oct 18;20(47):6851-63.

     2001

  • Tarapore P, Horn HF, Tokuyama Y, Fukasawa K. Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway. Oncogene.

    2001 May 31;20(25):3173-84.

     2001

  • Tokuyama Y, Horn HF, Kawamura K, Tarapore P, Fukasawa K. Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication. The Journal of Biological Chemistry.

    2001 Jun 15;276(24):21529-37.

     2001

  • Okuda M, Horn HF, Tarapore P, Tokuyama Y, Smulian AG, Chan PK, Knudsen ES, Hofmann IA, Snyder JD, Bove KE, Fukasawa K. Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell.

    2000 Sep 29;103(1)127-40.

     2000

  • Mussman JG*, Horn HF*, Carroll PE, Okuda M, Tarapore P, Donehower LA, Fukasawa K. Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression. Oncogene.

    2000 Mar 23;19(13)1635-46. *Co-first authors.

     2000

  • Carroll PE, Okuda M, Horn HF, Biddinger P, Stambrook PJ, Gleich LL, Li YQ, Tarapore P, Fukasawa K. Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression.

    Oncogene. 1999 Mar 18;18(11)1935-44.

     1999
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