People Biography

• Yeast lacking the PP2A phosphatase regulatory subunit Rts1 sensitizes rad51 mutants to specific DNA damaging agents. Front. Genet. 2019 Nov 8;10:1117. doi: 10.3389/fgene.2019.01117. eCollection 2019

• The Budding Yeast Saccharomyces Cerevisiae as A Model System for Anti-Cancer Drug Screening. Clinics of Oncology 1 (6) 1-3.

• Identification of essential yeast genes involved in polyamine resistance. Gene https://doi.org/10.1016/j.gene.2018.08.066 In press

• CRISPR/Cas9-mediated target validation of the splicing inhibitor Pladienolide B. Biochimie Open. 2016 Feb 24;3:72-75. doi: 10.1016/j.biopen.2016.02.001. eCollection 2016 Dec.

• Generation of an Efficient fdCas9 Synthetic Endonuclease with Improved Specificity for Precise Genome Engineering. PLoS One. 2015 Jul 30;10(7):e0133373. doi: 10.1371/journal.pone.0133373. eCollection 2015.

• Efficient Viral-Mediated Genome Editing in Plants using the CRISPR/Cas9 System (2015). Mol Plant. 2015 Mar 6. pii: S1674-2052(15)00162-8. doi: 10.1016/j.molp.2015.02.011

• The use of transcription activator- J Biosci Bioeng. 2015 Apr 20. pii: S1389-1723(15)00095-X. doi: 10.1016/j.jbiosc.2015.02.017

• RNA-guided transcriptional regulation in planta via synthetic dCas9- based transcription factors. Plant Biothechnology 2015 May; 13(4):578-89.

• Activities and Specificities of homodimeric TALENs in Saccharomyces cerevisiae. Current genetics (2013). In press

• A split luciferase method to identify Adiponectin receptors agonists using Saccharomyces cerevisiae as a model organism. PLoS One. 2013 Jun 7;8(6):e65454. doi: 10.1371/journal.pone.0065454. Print 2013

• AGP2 Encodes a Multifunctional Transceptor that Positively Regulates Polyamine Transport. PLoS One. 2013 Jun 3;8(6):e65717. doi: 10.1371/journal.pone.0065717. Print 2013

• Characterization and DNA Binding Specificities of Ralstonia TAL-like Effectors. Mol Plant. 2013 Jan 8.

• Book Chapter, DNA repair in cancer therapy Cancer Drug Discovery and Development (2012) Edited by Lawrence C. Panasci and Moulay A. Alaoui-Jamali In Press.

• Functional Characterization of Osput1 A Spermidine Preferential Transporter In Rice. Planta (2012) Jan;235(1):1-11.

• A potential transporter to revamp therapy with the anticancer drug bleomycin. Curr Drug Metab. 2010 Sep; 11(7):595-602.

• Internalization of a thiazole-modified peptide in Sinorhizobium meliloti occurs by BacA – dependent and independent mechanisms. Microbiology, 2010 Sep; 156(Pt 9): 2702 -13

• New Gateway to Treat Leukemia and Other Cancers, Science Daily (Mar, 27, 2010). http:// www.sciencedaily.com/releases/2010/03/100325113425.htm

• The Human Carnitine Transporter SLC22A16 Mediates High Affinity Uptake of the Anticancer Polyamine Analogue Bleomycin-A5 J. Biol. Chem. 2010 285: 6275-6284

• The Na+/H+ Exchanger Nhx1 of Saccharomyces cerevisiae is Essential to Limit Drug Toxicity. Advanced Studies in Biology, Vol. 2, 2010, no. 1, 15 – 34

• Novel role for the Saccharomyces cerevisiae oligopeptidetransporter Opt2 in vacuolar assembly and drug detoxification. Biochem and Cell Biology 2009: Vol 87 653-661.

• A potential mechanism of resistance to the anticancer drug bleomycin. In: Mohan RM, editor. Research Advances in Cancer: Vol., Part, Kerala, India, Global Research Network 247-260, 2007.

• Mitochondria-independent morphological and biochemical apoptotic alterations promoted by the antitumor agent bleomycin in S. cerevisiae. (2007) Biochemistry and Cell Biology. Vol. 85 No. 1 Pages 49-55.

• Bleomycin transport holds the key for improved anticancer therapy. Review Article. (2006). Cancer Therapy Vol 4, 171-182.

• A defect (spt10) in chromatin remodeling sensitizes yeast cells to a subclass of DNA damaging agents. (2006). Environ Mol Mutagen. 47(9):707-17.

• AGP2 encodes the major permease for high affinity polyamine import in Saccharomyces cerevisiae. J Biol Chem. (2005): 280(25): 24267-24276

• Isolation and characterization of Saccharomyces cerevisiae mutants with enhanced resistance to the anticancer drug bleomycin. Current Genet. 2004 May; 45(5):265-72

• A genome-wide screen in Saccharomyces cerevisiae reveals altered transport as a major mechanism of resistance to the anticancer drug bleomycin. Cancer Res. 2004 Feb 1; 64(3):1102-9.

• Characterization of the transport and detoxification pathway for the antitumor drug bleomycin in Saccharomyces cerevisiae. Biochem J. 2004 Nov 15; 384(Pt 1):47-58.

• Etude comparative de la cytotoxicité de deux antibiotiques antitumoraux, la bléomycine et laphléomycine, sur trois souches de la levure Saccharmyces cerevisiae. Microbiologie Hygiene et Alimentaire Vol. 16 :46 (2004) : 44-50.

• Comparative roles of cell wall and cell membrane in limiting xenobiotic molecules uptake by Saccharomyces cerevisiae. Antimicrobial Agents and Chemotherapy 2003 Jun; 47(6):2012-4.

• Yeast excellent model to study apoptosis. Microbiologie Hygiene et Alimentaire Vol.15 :42 (2003).

• 2005-2008 Post PhD fellowship from National Cancer Institute of Canada
• 2003-2005 Scholarship from Maisonneuve-Rosemont Foundation, Montreal (University of Montreal)
• 1999-2003 Scholarship from Tunisian Government and second scholarship from CNRS-France
• 1993-1999 Scholarship from Tunisian Government