QBRI Identifies 13 Novel Autism-risk Genes in Qatari Population

The Autism Genetics Program at Qatar Biomedical Research Institute (QBRI) has published an important study on autism spectrum disorder (ASD) within Qatar’s population. Led by Dr. Lawrence Stanton, former Director of the Neurological Disorders Research Center, this research casts further light on the genetic basis of the condition.

Over the course of this research, Dr. Afif Ben Mahmoud, Senior Research Associate, the lead author of the study at QBRI, identified 13 novel mutations in genes not previously associated with ASD. The team worked closely with the Shafallah Center for Children with Disabilities to enroll 50 Qatari autistic children and their parents. QBRI, in collaboration with Qatar Precision Health Institute (QPHI), determined the complete DNA sequences of the families’ genomes. From this enormous dataset, the team used advanced computational tools to reveal 13 genes that were not previously associated with autism risk. Ongoing efforts at QBRI are building on this and other recently published studies to shed light on the genetic basis of autism unique to the Arab world.

Commenting on the research’s publication, Dr. Omar Albagha, Acting Executive Director, QBRI, said: “These findings offer new insights into genetic factors contributing to autism in Qatar and may open new avenues for counseling and personalized treatment. The study also marks a significant advance in autism genetics and emphasizes the importance of studying ASD within diverse populations to enhance understanding of the disorder.”

Further information and the complete study can be accessed here. Previous studies can be found here and here.