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Dr. Mariam Al-Muftah
Scientist Joint Assistant Professor
Entity
Qatar Biomedical Research Institute
College of Health and Life Sciences
Divison
Translational Oncology Research Center
Biography
Dr. Mariam Al-Muftah received her BSc in Medical Genetics (Honors) from the University of Wales in the United Kingdom in 2005 and pursued her post graduated education to complete a Master of Research (MRes) in Biological Sciences in 2007 and a PhD of Medicine (cancer immunotherapy) as a joint project between the Cancer Research UK Manchester Institute and the University of Manchester in the United Kingdom. Her PhD project was focused on the use of a fully autologous mouse model to study immune regulation towards 5T4 targeted immunotherapies. Furthermore, she focused on the generation of novel chimeric antigen receptors against the tumor associated antigen 5T4.
After completing her doctoral degree in 2011, she became a lecturer of Biology at Qatar University and was later promoted to the rank of Assistant Professor. In February 2012, she was seconded to Qatar Biomedical Research Institute as a scientist to pursue her research interest. Recently, she completed an executive master program in Strategic Business Unit Management from HEC Paris University in Qatar. Dr. Mariam has taught several courses in general biology and molecular biology at the department of Biological and Environmental Sciences.
- Elucidating the mechanisms modulating triple negative breast cancer aggressiveness by dissecting intertumoral and intratumoral heterogeneity at the cellular and molecular levels, including immunophenotyping of the tumor microenvironment and identifying potential targets for the design of cancer immunotherapies.
- The role of cancer testis antigens in triple negative breast cancer and their potential as effective targets for T-cell based immunotherapy (a collaborative project with Dr. Julie Decock)
- Dr. Al-Muftah is also leading a project in collaboration with Dr. Lotfi Chouchane and Dr. Konduru Sastry from Weil Cornel Medical College in Qatar to understand the molecular mechanisms underlying the development of prostate cancer into the castration-resistant state, with the aim of identify key pro- and anti-apoptotic molecules and microRNAs that render prostate cancer cells at advanced stage resistant to therapy.
- Collaborator Name: Dr. Lotfi Chouchane Institute : WCM-Q Research Area : Prostate Cancer
- Collaborator Name: Dr. Konduru Sastry Institute : WCM-Q/SMRC Research Area : Prostate/Breast Cancer
- Collaborator Name: Dr. Julie Decock Institute : QBRI Research Area : Breast Cancer
- Collaborator Name: Dr. Said Dermime Institute : NCCCR - HMC Research Area : Cancer
- Collaborator Name: Dr. Nader AL-Dewik Institute : HMC Research Area : Hematological malignancies
- Collaborator Name: Dr. Shahinaz Bedri Institute : WCMCQ Research Area : Breast Cancer
MENTORING
Name: Summer Student Program (BSc level) Institution : Qatar University/Carnegie Mellon University in Qatar Period : May 2016 – July 2016
MENTORING
Name: PhD Student Institution : Hamad Bin Khalifa University Period : 2016-
List of Publications on Pubmed.