Dr. Bernice Lo

Dr. Bernice Lo

Assistant Professor

blo@sidra.org

Phone

+974 4003 7385

Office location

Sidra Medicine, OPC - C5.325

Dr. Bernice Lo

Assistant Professor

Educational Qualifications

PhD in Cell & Molecular Biology

BS in Microbiology & Cell Science

Entity

College of Health and Life Sciences

Biography

Bernice Lo is an Assistant Professor at the College of Health and Life Sciences at Hamad Bin Khalifa University and an investigator at Sidra Medicine. Her research focuses on understanding the molecular mechanisms of immune regulation and tolerance. Her work includes identifying the genetic basis of disease in patients with immune dysregulation and autoimmunity. The ultimate goal is to elucidate the molecular pathways involved and, therefore, discover new therapeutic targets for disease treatment or novel drugs for immunomodulation.

She has made significant contributions to discovering, understanding, and diagnosing various genetic disorders of immune dysregulation. Dr. Lo’s lab specializes in using cellular and biochemical techniques to uncover the role of newly discovered gene mutations in causing disease and in understanding the function of these genes in immune regulation. She is also interested in developing methods for disease diagnosis or evaluating treatment efficacy by assessing immune biomarkers.

PhD in Cell & Molecular Biology

Duke University, United States

2008

BS in Microbiology & Cell Science

University of Florida, United States

2002

Molecular mechanisms of immune regulation
Primary immunodeficiency disorders / Inborn errors of immunity
Monogenic immune dysregulation diseases
Immunogenetics

Assistant Professor

College of Health and Life Sciences, Hamad Bin Khalifa University

2018 - Present

Investigator

Division of Translational Medicine, Sidra Medicine

2016 - Present

Research Fellow

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases (NIAID/NIH), United States

2013 - 2015

Post-Doctoral Fellow

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases (NIAID/NIH), United States

2008 - 2013

Capitani, M., Al-Shaibi, A. A., Pandey, S., Gartner, L., Taylor, H., Hubrack, S. Z., Agrebi, N., Al-Mohannadi, M. J., Al Kaabi, S., Vogl, T., Roth, J., Kotlarz, D., Klein, C., Charles, A. K., Vijayakumar, V., Karim, M. Y., George, B., Travis, S. P., Elawad, M., & Uhlig, H. H. (2023). Biallelic TLR4 deficiency in humans. Journal of Allergy and Clinical Immunology, 151(3), 783-790.e5.

Kubo, S., Fritz, J. M., Raquer-McKay, H. M., Kataria, R., Vujkovic-Cvijin, I., Al-Shaibi, A., Yao, Y., Zheng, L., Zou, J., Waldman, A. D., Jing, X., Farley, T. K., Park, A. Y., Oler, A. J., Charles, A. K., Makhlouf, M., AbouMoussa, E. H., Hasnah, R., Saraiva, L. R., & Lenardo, M. J. (2022). Congenital iRHOM2 deficiency causes ADAM17 dysfunction and environmentally directed immunodysregulatory disease. Nature Immunology, 23(1), 75-85.

Agrebi, N., Gentilcore, G., Grivel, J. C., Alkhayer, G., Hassoun, J., Hassan, A., Adeli, M., & Lo, B. (2021). X-linked agammaglobulinemia case with TH domain missense mutation in Bruton tyrosine kinase. Journal of Clinical Immunology, 41(4), 825-828.

Al-Shaibi, A. A., Abdel-Motal, U. M., Hubrack, S. Z., Bullock, A. N., Al-Marri, A. A., Agrebi, N., Al-Subaiey, A. A., Ibrahim, N. A., Charles, A. K., Group, C. I.-Q. S., Elawad, M., Uhlig, H. H., & Lo, B. (2021). Human AGR2 deficiency causes mucus barrier dysfunction and infantile inflammatory bowel disease. Cellular and Molecular Gastroenterology and Hepatology, 12(5), 1809-1830.

Lo, B., Zhang, K., Lu, W., Zheng, L., Zhang, Q., Kanellopoulou, C., Zhang, Y., Liu, Z., Fritz, J. M., Marsh, R., Husami, A., Kissell, D., Nortman, S., Chaturvedi, V., Haines, H., Young, L. R., Mo, J., Filipovich, A. H., Bleesing, J. J., & Jordan, M. B. (2015). Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy. Science, 349(6246), 436-440.

Complete Publication Listing(s): PubMed

2022; Top Author – Junior Investigator Category; Sidra Medicine
2013; AAI Trainee Award; American Association of Immunologists Annual Meeting
2002-2006; James B. Duke Fellowship; Duke University, NC, USA
2002; Four-Year Scholar; University of Florida, FL, USA
2001; Peterson Scholarship; University of Florida, FL, USA

People Biography

Dr. Bernice Lo

Dr. Bernice Lo

Biography

Education

PhD in Cell & Molecular Biology

BS in Microbiology & Cell Science

Research Interests

Experience

Assistant Professor

Investigator

Research Fellow

Post-Doctoral Fellow

Selected Publications

Honors & Awards